Completed Research HIV DRDB PROJECT

HIV DRDB PROJECT

Project- HIV DRDB Project

Title of the study - Development of a National HIV Drug Resistance Database by Generating and Utilizing Clinical, Genotypic and Phenotypic Characterization Data of the Prevalent Drug Resistant Strains of Indian HIV-1 Clade C

About the project: As very limited data on HIV drug resistance is available in India, generating HIVDR sequence database for Indian HIV-1 Clade C is of prime importance. The proposed study will attempt to establish network of ART sites and centres where genotypic drug resistance assays are being done to develop a database on pol gene sequences and mutations, to collect the clinical data to link it with genotyping data and to carry out phenotypic resistance assays to assess the association of novel mutations with HIV drug resistance. The technological tools will be developed for phenotypic drug resistance and replication fitness studies of a subset of Indian HIV-1 Clade C resistant viruses and develop a preliminary database for phenotypic drug resistance in India.  The national HIV drug resistance database in the form of web resource will be developed for submission, analysis and retrieval of genotypic and phenotypic data related to HIV drug resistance in the country

Objective of the project-

1) To develop the network of genotyping laboratories andclinical sites that treat HIV infected persons with First line and second line treatment regimens.

2) To develop a national HIV drug resistance database with clinical and treatment history of patients failing on anti-retroviral treatment, genotyping for identifying drug resistance mutations and collection of phenotypic drug resistance data. 

3) To develop phenotypic resistance and fitness assays for the Indian HIV-1 Clade C.

Study setting- It was a Multicenter study. From each site 20 blood samples from patients failing on first –line treatment were collected for genotyping and phenotyping. Prayas was one of the sites.

Principal Investigator- Dr. Srikanth P. Tripathy,Scientist ‘F’ National AIDS Research Institute, (Indian Council of Medical Research)

 Supported by – Indian Council of Medical research (ICMR)

 Duration for sample collection- Jan 2014 - June 2014

 

Prayas-Amrita Clinic, Athawale Corner, Karve Road, Deccan Gymkhana, Pune - 411 004, Maharashtra, India.
Tel.: +91-20-25441230/65615726 Tel./Fax: +91+20-25420337 E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.